Diisopropylethylamine → 3-(2-(1H-1,2,3-Triazol-1-yl)ethyl)-5-fluoro-1H-indole

HRID 1095514노트

반응식

HRID 1095514 반응식
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[NH:6][CH:5]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[N:15]1.C(N(C(C)C)C(C)C)C>C(Cl)(Cl)Cl>[N:14]1([CH2:2][CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=3)[NH:6][CH:5]=2)[CH:18]=[CH:17][N:16]=[N:15]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 112072263-(2-bromoethyl)-5-fluoro-1H-indoleHCID 178418936HCID 178418936, 화합물

생성물 1

HCID 574751383-(2-(1H-1,2,3-Triazol-1-yl)ethyl)-5-fluoro-1H-indole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 3-(2-bromo-ethyl)-5-fluoro-1H-indole (7.26 g, 30 mmol), 1,2,3-triazole (2.07 g, 30 mmol) and ethyl-diisopropylamine (5.1 ml, 30 mmol) in abs. chloroform (70 ml) was boiled under reflux for 24 h. The reaction solution was then washed twice with water, dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1).).

후처리

  1. temperatureunder reflux for 24 h
  2. washThe reaction solution was then washed twice with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated i
  5. customand the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1)

출처 및 근거

ORD 기록
ord-7e91131777cc46caab60710ed4e1658c
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138187B2

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