Hydrochloric Acid → 4-[Benzo(B)thiophen-2-YL]benzoic acid

HRID 1096945노트

반응식

HRID 1096945 반응식
[OH-].[Na+].[S:3]1[C:7]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2.Cl>CO>[S:3]1[C:7]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4137384Methyl 4-benzo[b]thien-2-ylbenzoate

생성물 1

HCID 41373834-[Benzo(B)thiophen-2-YL]benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Aqueous 5 N sodium hydroxide solution (0.28 mL, 1.40 mmol) was added to a methanol (2.3 mL) solution of methyl 4-(benzo[b]thiophen-2-yl)benzoate (124 mg, 0.462 mmol), and refluxed for 3 hours. After left cooled, 5 N hydrochloric acid (0.28 mL, 1.40 mmol) was added to the reaction mixture, and concentrated under reduced pressure. 20% methanol/THF was added to the residue, the mixture was filtered, and the filtrate was concentrated under reduced pressure. Diethyl ether was added to the residue, the insoluble matter was taken out through filtration, and dried to obtain the title compound as a pale yellow solid.

후처리

  1. temperaturerefluxed for 3 hours
  2. waitAfter left
  3. temperaturecooled
  4. concentrationconcentrated under reduced pressure
  5. addition20% methanol/THF was added to the residue
  6. filtrationthe mixture was filtered
  7. concentrationthe filtrate was concentrated under reduced pressure
  8. additionDiethyl ether was added to the residue
  9. filtrationthe insoluble matter was taken out through filtration
  10. customdried

출처 및 근거

ORD 기록
ord-aceecb72c08044efa61324c70ee2de39
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

반응 노트

불러오는 중…