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Hydrochloric Acid → Methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate

HRID 1096952
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인쇄 미리보기

반응식

HRID 1096952 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].Cl.C(N(CC)CC)C.[C:13]([C:15]1[CH:16]=[C:17]([C:27]([O:29][CH3:30])=[O:28])[CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:20]=1)#[N:14].Cl>CN(C=O)C>[NH:1]1[C:13]([C:15]2[CH:16]=[C:17]([C:27]([O:29][CH3:30])=[O:28])[CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:20]=2)=[N:14][N:3]=[N:2]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 57346364Methyl 5-cyano-[1,1'-biphenyl]-3-carboxylate

생성물 1

HCID 178497260Methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide
용매

반응 조건

온도
100 °C

실험 절차

Sodium azide (880 mg) and triethylamine hydrochloride (1.9 g) were added to a DMF (40 mL) solution of methyl 5-cyanobiphenyl-3-carboxylate (1.09 g), and stirred at 100° C. for 9 hours. With cooling with ice, diluted hydrochloric acid was added to it, the formed precipitate was taken out through filtration, washed with water, and dried to obtain the title compound as a white powder.

후처리

  1. additionwas added to it
  2. filtrationthe formed precipitate was taken out through filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-624b9471f1da4ca598e4564e5ceafbcb
출처 데이터셋
uspto-grants-2012_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08138197B2

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