Hydrochloric Acid → 3,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

HRID 1096991노트

반응식

HRID 1096991 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([O:9]C)=[O:8])[CH3:2].Cl>CO.C1COCC1.[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([OH:9])=[O:8])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57931014Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate

생성물 1

HCID 579309183,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

시약·촉매·용매 2

HCID 14798Sodium Hydroxide용매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate (91 mg) was dissolved in a mixed solvent of methanol/THF (8 mL, 3/5), aqueous 1 M NaOH solution (1.2 mL) was added to it, and stirred at room temperature for 5 hours. Aqueous 1 M HCl solution (1.2 mL) was added to it, and the solvent was concentrated under reduced pressure. The formed solid was taken out through filtration, washed with water, and dried under reduced pressure to obtain the title compound as a pale yellow solid.

후처리

  1. additionwas added to it
  2. concentrationthe solvent was concentrated under reduced pressure
  3. filtrationThe formed solid was taken out through filtration
  4. washwashed with water
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-553a18b38cc445e484a6466a8808f0a3
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

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