Epichlorohydrin → 10-(2-Ethylhexyloxy)decyl glycidyl ether

HRID 1097

반응식

HRID 1097 반응식
[CH2:1]([CH:3]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][OH:16])[CH3:2].[CH2:21]([CH:23]1[O:25][CH2:24]1)Cl.[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.CCCCCC>[CH2:21]([O:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][O:5][CH2:4][CH:3]([CH2:1][CH3:2])[CH2:17][CH2:18][CH2:19][CH3:20])[CH:23]1[O:25][CH2:24]1

참가 물질

6

반응물 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 1969464710-(2-Ethylhexyloxy)decanol

생성물 1

HCID 1969463510-(2-Ethylhexyloxy)decyl glycidyl ether수율 82.6%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 8058Hexane용매

반응 조건

온도
40 °C

실험 절차

A 200-ml flask equipped with a stirrer, reflux tube and dropping funnel was charged with 24.8 g (87 mmol) of 10-(2-ethylhexyloxy)decanol, 17.7 g (0.191 mol) of epichlorohydrin, 1.4 g (4.4 mmol) of tetrabutylammonium bromide and 25 ml of hexane. While stirring the mixture at 40° C., 29.2 g (0.35 mol) of a 48% aqueous solution of NaOH were added dropwise over 3 hours. After completion of the dropping, the stirring was continued further for 2 hours at 40° C. After the resultant reaction mixture was washed with water, and the solvent was distilled off under reduced pressure, the resultant residue was purified by column chromatography on silica gel, thereby obtaining 24.6 g (yield: 82.6%) of 10-(2-ethylhexyloxy)decyl glycidyl ether.

후처리

  1. customA 200-ml flask equipped with a stirrer
  2. temperaturereflux tube
  3. customAfter the resultant reaction mixture
  4. washwas washed with water
  5. distillationthe solvent was distilled off under reduced pressure
  6. customthe resultant residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-aca60743900142f7968a0bb1a46a2668
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723497

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