Hydrochloric Acid → [3-Methyl-4-(methylthio)phenyl]methanol
반응식
[BH4-].[Na+].[CH3:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[S:12][CH3:13])[CH:7]=[O:8].Cl>C(O)C>[CH3:3][C:4]1[CH:5]=[C:6]([CH2:7][OH:8])[CH:9]=[CH:10][C:11]=1[S:12][CH3:13]참가 물질
5
실험 절차
Sodium borohydride (1.40 g, 0.037 mol) was added to an ice-bath cooled solution of the product of example 28 step a) (6.16 g, 0.037 mol) in ethanol (50 ml). After 1 hour, the reaction mixture was neutralised by careful addition of aqueous hydrochloric acid (2 molar) and concentrated in vacuo to remove the organic solvent. The remaining aqueous solution was then extracted with ethyl acetate (×3). The combined organic layers were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to yield the subtitle compound as a brown oil (6 g) in quantitative yield.
후처리
- concentrationconcentrated in vacuo
- customto remove the organic solvent
- extractionThe remaining aqueous solution was then extracted with ethyl acetate (×3)
- dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0cdd2c7fbed5402c931c255b269ab1be
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08143261B2
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