Water → HCID 178513306, 화합물

HRID 1097699노트

반응식

HRID 1097699 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].C(=O)([O-])[O-].[K+].[K+].[OH2:15].Cl.[NH2:17]O>CCO>[OH:15][NH:8][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[NH:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 7522Pyridine-2-carbonitrileHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 178513306HCID 178513306, 화합물수율 57%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of 2-pyridinecarbonitrile (3 g, 29 mmol) and potassium carbonate (4.1 g, 30 mmol) in EtOH (30 ml) was added water (15 ml) and, cautiously, hydroxylamine hydrochloride (2.9 g, 42 mmol) and then heated at reflux for 6 h, cooled and evaporated to dryness. The residue was treated with water (100 ml) and the suspended solid product filtered off, washed with water and dried to yield the title compound as a white solid (2.28 g, 57%).

후처리

  1. temperatureat reflux for 6 h
  2. temperaturecooled
  3. customevaporated to dryness
  4. additionThe residue was treated with water (100 ml)
  5. filtrationthe suspended solid product filtered off
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-a94e094ee67548509da3f39dbe15a321
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143264B2

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