Hydrochloric Acid → 4-Hydroxy-1,3,3-trimethyl-3,4-dihydroquinolin-2(1H)-one
반응식
[BH4-].[Na+].[CH3:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[C:6]([CH3:16])([CH3:15])[C:5]1=[O:17].Cl>CCO>[OH:14][CH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]([CH3:3])[C:5](=[O:17])[C:6]1([CH3:16])[CH3:15]참가 물질
5
실험 절차
NaBH4 (excess amount) is added to a solution of 1,3,3-Trimethyl-1H-quinoline-2,4-dione (330 mg, 1.62 mmol) in EtOH (8 mL) at 0° C. The resulting mixture is slowly warmed up to room temperature. After 1 h, HCl (10%, 3 mL) is added dropwise. The solvent is removed under vacuum, the residue is dissolved into ether and washed with water, brine, and dried over anhydrous Na2SO4. After concentration, the title compound is yielded (275 mg, 82% yield).
후처리
- customThe solvent is removed under vacuum
- dissolutionthe residue is dissolved into ether
- washwashed with water, brine
- dry with materialdried over anhydrous Na2SO4
- concentrationAfter concentration
출처 및 근거
- ORD 기록
- ord-c63cda62eac443e8bccd8558c3f3c63a
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08143278B2
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