Methyl iodide → Methyl 2-bromo-6-methylbenzoate

HRID 1097976

반응식

HRID 1097976 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].CI.[C:14](=O)([O-])O.[K+]>CN(C=O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([O:6][CH3:14])=[O:5]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 516893Potassium BicarbonateHCID 27355892-Bromo-6-methylbenzoic acid

생성물 1

HCID 11564857Methyl 2-bromo-6-methylbenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2-bromo-6-methylbenzoic acid (5.02 g) and methyl iodide (2.9 mL) in N,N′-dimethylformamide (30 mL) was added powdered potassium hydrogen carbonate (4.67 g). The mixture was stirred at ambient temperature for 16 hours and concentrated. The concentrate was partitioned between ethyl acetate and water. The extract was washed with brine and concentrated, and the concentrate was purified by flash chromatography on silica gel with 60% ethyl acetate in hexanes.

후처리

  1. concentrationconcentrated
  2. customThe concentrate was partitioned between ethyl acetate and water
  3. washThe extract was washed with brine
  4. concentrationconcentrated
  5. customthe concentrate was purified by flash chromatography on silica gel with 60% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-95ffc6b7216c47e0afcf67899bff3076
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143284B2

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