Sodium Hydroxide → 3-cyclopentyl-5-Isoxazolamine

HRID 1098565노트

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HRID 1098565 반응식
Cl.[NH2:2][OH:3].[CH:4]1([C:9](=O)[CH2:10][C:11]#[N:12])[CH2:8][CH2:7][CH2:6][CH2:5]1.[OH-].[Na+]>O>[CH:4]1([C:9]2[CH:10]=[C:11]([NH2:12])[O:3][N:2]=2)[CH2:8][CH2:7][CH2:6][CH2:5]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 135921183-Cyclopentyl-3-oxopropanenitrile

생성물 1

HCID 133773103-cyclopentyl-5-Isoxazolamine수율 61%

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

Hydroxylamine hydrochloride (6 g, 86 mmol) and 3-cyclopentyl-3-oxopropanenitrile (10 g, 73 mmol) were added to a solution of NaOH (9 g, 225 mmol) in water (100 mL) and the resulting mixture was heated at 50° C. overnight. The precipitate was collected by filtration, washed with water, and dried to give 3-cyclopentylisoxazol-5-amine (6.7 g, 61% yield). 1H NMR (400 MHz, DMSO-d6): δ 6.43 (s, 2 H), 4.77 (s, 1 H), 2.84 (m, 1 H), 1.87-1.51 (m, 8 H); MS (ESI) m/z: 153.1 (M+H+).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-7c2cef6077c143d68e2b5d5ccc3d4a93
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143293B2

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