Phenol → 2-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenoxy}propanoic acid

HRID 1105725

반응식

HRID 1105725 반응식
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH:27]([CH3:31])[C:28]([OH:30])=[O:29].C1(O)C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>O.O1CCOCC1>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH:27]([CH3:31])[C:28]([OH:30])=[O:29])=[CH:9][CH:10]=1

참가 물질

8

반응물 5

HCID 996PhenolHCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 117342-Chloropropionic acidHCID 129406134-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol

생성물 1

HCID 129060172-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenoxy}propanoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

28.9 g of 4-(2-chloro-4-trifluoromethylphenoxy)phenol was added to 50 ml of dioxane, and with stirring at 30° to 40° C., 13.8 g of potassium carbonate was added. The mixture was heated to 40° to 60° C., and 10.8 g of α-chloropropionic acid was added. The reaction was performed for 4 hours. The disappearance of the starting phenol was confirmed by gas chromatography, and the reaction product was poured into a suitable amount of water. Sodium carbonate was added to transfer the final product into the aqueous phase. The oily phase was separated and removed, and then hydrochloric acid was added to afford 20 g of a solid precipitate. The final product obtained had a melting point of 90° to 92° C.

후처리

  1. temperatureThe mixture was heated to 40° to 60° C.

출처 및 근거

ORD 기록
ord-e359c2285da843bc96ccd00dfaacad22
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04309562

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