Oxalic Acid → HCID 15524196, 화합물

HRID 1106432노트

반응식

HRID 1106432 반응식
[Br:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[C:9]([NH2:15])=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:7]2.[C:25](O)(=[O:29])[C:26](O)=[O:27]>Cl>[Br:1][C:2]1[C:3]2[CH2:4][CH2:5][N:6]([CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:7][C:8]=2[C:9]2[NH:15][C:25](=[O:29])[C:26](=[O:27])[NH:12][C:10]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 971Oxalic AcidHCID 155241945-Bromo-1,2,3,4-tetrahydro-7-nitro-2-(3-phenylpropyl)-8-isoquinolinamine

생성물 1

HCID 15524196HCID 15524196, 화합물수율 60.3%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of the product from Example 12 (0.98 g, 2.72 mmol) in 3N HCl (35 mL) was treated with oxalic acid (0.36 g, 2.86 mmol) and refluxed for five hours. When cool to room temperatures the precipitate was filtered, suspended in water (70 mL) and basifyed to pH 8. The solids were filtered, and dried to give the title compound (0.68 g, 60%) as a brown solid, mp=288-293° C.

후처리

  1. temperaturerefluxed for five hours
  2. temperatureWhen cool to room temperatures the precipitate
  3. filtrationwas filtered
  4. filtrationThe solids were filtered
  5. customdried

출처 및 근거

ORD 기록
ord-ebeecbeca3644c59b97b3ab96acdbe55
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057313

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