Water → Hydroxypropyl bispalmitamide monoethanolamide

HRID 1107611노트

반응식

HRID 1107611 반응식
[O-2:1].[Mg+2].O.[OH:4][CH2:5][CH2:6][NH:7][CH2:8][CH:9]([OH:15])[CH2:10][NH:11][CH2:12][CH2:13][OH:14].[C:16](Cl)(=[O:32])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>O1CCOCC1>[OH:4][CH2:5][CH2:6][N:7]([C:31](=[O:1])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH3:16])[CH2:8][CH:9]([OH:15])[CH2:10][N:11]([C:16](=[O:32])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:12][CH2:13][OH:14]

참가 물질

6

반응물 4

HCID 962WaterHCID 8206Palmitoyl chlorideHCID 30392362-Propanol, 1,3-bis((2-hydroxyethyl)amino)-HCID 6850729Magnesium monoxide

생성물 1

HCID 11193108Hydroxypropyl bispalmitamide monoethanolamide수율 76.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Subsequently, into a 500 ml rounded-flask, were introduced 4.0 g of magnesium oxide and 80 g of distilled water. The mixture was stirred, and was added 8.9 g of N,N'-bis(2-hydroxyethyl)-2-hydroxy-1,3-propanediamine prepared above, and then was added 250 ml of 1,4-dioxane. 26.8 g of palmitoyl chloride was gradually added dropwise to the resulting mixture for 1 hour under violent stirring at a room temperature. After stirring for 2 hours, the mixture was filtered, and then the filtrate was mixed with 200 ml of chloroform, and washed twice with 200 ml of distilled water. The organic phase was seperated; on cooling a precipitated, which was collected and recrystallized from acetone, to give 24.3 g of the title compound as white powder, which was identified by IR and NMR. The results are shown in Table 4.

후처리

  1. customprepared above, and
  2. stirringunder violent stirring at a room temperature
  3. stirringAfter stirring for 2 hours
  4. filtrationthe mixture was filtered
  5. additionthe filtrate was mixed with 200 ml of chloroform
  6. washwashed twice with 200 ml of distilled water
  7. customThe organic phase was seperated
  8. temperatureon cooling a precipitated, which
  9. customwas collected
  10. customrecrystallized from acetone

출처 및 근거

ORD 기록
ord-cf4fc473027f4db890415995122909db
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060612

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