Sodium borohydride → (4-Bromo-7-methoxybenzofuran-2-yl)-methanol

HRID 1108317노트

반응식

HRID 1108317 반응식
[BH4-].[Na+].[CH:3]([C:5]1[O:6][C:7]2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=[C:10]([Br:16])[C:8]=2[CH:9]=1)=[O:4]>C(O)CCC>[Br:16][C:10]1[C:8]2[CH:9]=[C:5]([CH2:3][OH:4])[O:6][C:7]=2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 187848644-Bromo-7-methoxy-1-benzofuran-2-carbaldehyde

생성물 1

HCID 18784868(4-Bromo-7-methoxybenzofuran-2-yl)-methanol수율 86%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

Sodium borohydride (1.12 g) was added portionwise to a stirred solution of 2-formyl-4-bromo-7-methoxybenzofuran (30 g) in 1-butanol (150 ml) at ambient temperature. After stirring for 1 h the reaction was quenched by the addition of 2M hydrochloric acid (100 ml) and stirred overnight. The mixture was separated and the organic phase washed with water (200 ml). The combined aqueous phases were extracted with tert-butyl methyl ether (100 ml). The organic phases were combined and concentrated in vacuo followed by drying in vacuo at 60° C. to afford the title compound as a brown solid (26 g).

후처리

  1. customwas quenched by the addition of 2M hydrochloric acid (100 ml)
  2. stirringstirred overnight
  3. customThe mixture was separated
  4. washthe organic phase washed with water (200 ml)
  5. extractionThe combined aqueous phases were extracted with tert-butyl methyl ether (100 ml)
  6. concentrationconcentrated in vacuo
  7. customby drying in vacuo at 60° C.

출처 및 근거

ORD 기록
ord-d7b26369c3a54cf6bc0c68d78ec08041
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066657

반응 노트

불러오는 중…