Hydrochloric Acid → N-(allyloxycarbonyl)glycine methyl ester

HRID 1111050

반응식

HRID 1111050 반응식
[CH2:1]([O:4][C:5]([NH:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6])[CH:2]=[CH2:3].Cl.[C:13](=O)(O)[O-].[Na+]>CO>[CH3:13][O:10][C:9](=[O:11])[CH2:8][NH:7][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[O:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 11964402N-[(allyloxy)carbonyl]glycine

생성물 1

HCID 22154858N-(allyloxycarbonyl)glycine methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.06 mol of N-(allyloxycarbonyl)glycine, prepared as described by F. Guibe, O. Dangles, and G. Balavione in Tetrahedron Letters, 1986, 27, 2365-2368, and 0.066 mol of HCl in 100 mL of CH3OH is stirred at reflux for 8 hours. The solution is then cooled and treated with 0.066 mol of sodium bicarbonate. The solvent is removed by rotary evaporator, and the residue is dissolved in diethyl ether, filtered, dried over MgSO4, and filtered. The solvent is removed by rotary evaporator to give N-(allyloxycarbonyl)glycine methyl ester.

후처리

  1. temperatureat reflux for 8 hours
  2. temperatureThe solution is then cooled
  3. customThe solvent is removed by rotary evaporator
  4. dissolutionthe residue is dissolved in diethyl ether
  5. filtrationfiltered
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. customThe solvent is removed by rotary evaporator

출처 및 근거

ORD 기록
ord-c6d3ef9add384eb29b0cd1b055b59e8a
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04977272

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