Hydrochloric Acid → alpha-Phenyl[1,1'-biphenyl]-4-methanol

HRID 1111656

반응식

HRID 1111656 반응식
[C:1]1([C:7]2[CH:20]=[CH:19][C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].O.Cl>C(O)C>[C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=[CH:9][C:10]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[OH:12])=[CH:19][CH:20]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 750404-BenzoylbiphenylHCID 4311764Sodium borohydride

생성물 1

HCID 95512alpha-Phenyl[1,1'-biphenyl]-4-methanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

38.8 g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol and 3 g (0.075 mol) of sodium borohydride are added. After heating for 15 hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed with water containing a little hydrochloric acid. The solid thereby produced is purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl-4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α-(biphenyl-4-yl)benzylalcohol] of melting point 72°-73° C. are obtained.

후처리

  1. temperatureAfter heating for 15 hours
  2. temperatureunder reflux
  3. temperatureto cool
  4. customThe solid thereby produced
  5. customis purified by recrystallization from ethanol
  6. customare obtained

출처 및 근거

ORD 기록
ord-45182ab4d29b44818040161a2a1e24d8
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04118487

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