Hydrochloric Acid → HCID 178474231, 화합물

HRID 1112313노트

반응식

HRID 1112313 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N+:6]=1[O-:12])(=[O:3])[CH3:2].[SH-:13].[Na+].Cl>C(O)C>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([SH:13])[N+:6]=1[O-:12])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 178474109HCID 178474109, 화합물

생성물 1

HCID 178474231HCID 178474231, 화합물수율 79%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2 gms (0.0087 mole) of 2-acetamido-6-bromopyridine-1-oxide was suspended in 35 ml (0.035 mole) of 1M aqueous sodium hydrosulfide and 30 ml of ethanol and agitated at 60° C for 5 hours and at room temperature one night. Concentrated hydrochloric acid was added dropwise to the cold yellow solution and the precipitated solid filtered, giving a 79% yield of 2-acetamido-6-mercaptopyridine-1-oxide. This impure product was purified by recrystallization from 2-propanol and hot filtration to remove a small amount of contaminating sulfur to give pale yellow crystals, m.p.=172.8°-173.5° C.

후처리

  1. filtrationthe precipitated solid filtered

출처 및 근거

ORD 기록
ord-d0010f571d564be4a8bbc56f37c3e2ab
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122084

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