N,N-Dimethylaniline → 8-Fluoro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzothiazepine

반응식

[CH3:26][N:27]([c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[CH3:34].[CH3:35][N:36]1[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]1.[F:1][c:2]1[cH:3][c:4]2[c:5]([cH:19][cH:20]1)[NH:6][C:7](=[O:18])[c:8]1[c:9]([s:11][c:12]3[c:13]1[cH:14][cH:15][cH:16][cH:17]3)[S:10]2.[P:21]([Cl:22])([Cl:23])([Cl:24])=[O:25]>>[F:1][c:2]1[cH:3][c:4]2[c:5]([cH:19][cH:20]1)[N:6]=[C:7]([N:39]1[CH2:38][CH2:37][N:36]([CH3:35])[CH2:41][CH2:40]1)[c:8]1[c:9]([s:11][c:12]3[c:13]1[cH:14][cH:15][cH:16][cH:17]3)[S:10]2