Hydrochloric Acid → 2-Methylindol-4-yloxyacetic Acid

HRID 11410노트

반응식

HRID 11410 반응식
C[O:2][C:3](=[O:16])[CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[CH3:5].O1CCOCC1.[OH-].[Na+].Cl>CO>[CH3:5][CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[C:3]([OH:16])=[O:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 691303762-Methylindol-4-yloxyacetic Acid Methyl Ester

생성물 1

HCID 695893972-Methylindol-4-yloxyacetic Acid수율 69.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-methylindol-4-yloxyacetic acid methyl ester (5.4 g) in methanol (18 ml)—dioxane (36 ml) was added 5N aqueous solution of sodium hydroxide (15 ml), and the mixture was stirred at room temperature for 1 hour. To the reaction solution was added 2N hydrochloric acid to give the title compound (3.5 g) having the following physical data.

출처 및 근거

ORD 기록
ord-9780cbde62544c4190fa07986e5ceffd
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098234B2

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