1-Bromodecane → 1-Decylpyrrolidin-2-one

HRID 1155104노트

반응식

HRID 1155104 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17].CC([O-])(C)C.[K+]>CS(C)=O>[CH2:2]([N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 81731-BromodecaneHCID 120252-PyrrolidoneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 1714271-Decylpyrrolidin-2-one

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

22.1 g 1-Bromodecane (0.1 mol), 8.5 g (0.1 mol) of 2-pyrrolidone and 11.2 g (0.1 mol) of potassium tert-butylate were stirred in 100 ml of absolute DMSO for one hour. The DMSO was removed under reduced pressure, the residue taken up with diethyl ether, and washed with water (2 times). After drying with anhydrous MgSo4 and evaporating, the residue was distilled in vacuo. A first fraction, boiling between 140° and 147° C./1.2 mm Hg was discarded. The second fraction 17.4 g of pure product, b.p. 148° C./1.2 mm Hg.

후처리

  1. customThe DMSO was removed under reduced pressure
  2. washwashed with water (2 times)
  3. customAfter drying with anhydrous MgSo4
  4. customevaporating
  5. distillationthe residue was distilled in vacuo
  6. customboiling between 140° and 147° C.

출처 및 근거

ORD 기록
ord-70989bcb84964edaa37a7e890bb5524a
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04299840

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