Hydrochloric Acid → 4(2-Chlorophenyl)phenacyl chloride

HRID 1155283

반응식

HRID 1155283 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Cl:18][CH2:19][C:20](Cl)=[O:21].Cl>C(Cl)Cl>[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:13]=[CH:14][C:15]([C:20](=[O:21])[CH2:19][Cl:18])=[CH:16][CH:17]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 2492662-ChlorobiphenylHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 205617034(2-Chlorophenyl)phenacyl chloride수율 90.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

293.7 g (2.2 mols) of aluminium chloride are introduced in portions to a solution of 377 g (2 mols) of 2-chlorobiphenyl in 160 ml (2 mols) of chloroacetyl chloride and 1,000 ml of methylene chloride. After 18 hours, the reaction mixture is poured onto ice and hydrochloric acid. The organic phase is seperated off, washed, dried over sodium sulphate and concentrated in vacuo by distilling off the solvent. The oil which remains is purified by distillation. 478.7 g (90% of theory) of 4(2-chlorophenyl)phenacyl chloride of melting point 47° C. are obtained.

후처리

  1. customThe organic phase is seperated off
  2. washwashed
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated in vacuo
  5. distillationby distilling off the solvent
  6. distillationThe oil which remains is purified by distillation

출처 및 근거

ORD 기록
ord-ccd0f74643d54f44a9896a5ebe12eec2
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04301166

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