Water → HCID 136359197, 화합물

HRID 1155541노트

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HRID 1155541 반응식
Cl.[NH2:2][OH:3].O.[OH-].[Na+].[CH2:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16](=O)[CH3:17])[CH:13]=[CH:12][N:11]=1)[CH3:8]>CO>[CH2:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16](=[N:2][OH:3])[CH3:17])[CH:13]=[CH:12][N:11]=1)[CH3:8]

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 131452661-(2-Ethylamino-4-pyridyl)-1-ethanone

생성물 1

HCID 136359197HCID 136359197, 화합물수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 7 g. (0.1 mole) of hydroxylamine hydrochloride in 40 ml. of water and 50 ml. of 2 N sodium hydroxide was added 11.5 g. (70 mmoles) of 1-(2-ethylamino-4-pyridyl)-1-ethanone, and the resulting mixture heated to boiling. Methanol was carefully added until the mixture became homogeneous. Heating was continued until the mixture became cloudy. The mixture was cooled and the resulting precipitate filtered, washed with water and dried. Recrystallization from toluene gave 10.9 g. (87%) of the desired product, m.p. 155°-156° C.

후처리

  1. additionTo a mixture of 7 g
  2. temperatureHeating
  3. temperatureThe mixture was cooled
  4. filtrationthe resulting precipitate filtered
  5. washwashed with water
  6. customdried
  7. customRecrystallization from toluene
  8. customgave 10.9 g

출처 및 근거

ORD 기록
ord-326e57327d40407a9207cc1b20120c85
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04302464

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