Hydrochloric Acid → 2-(Acetoxymethyl)benzenesulfonamide
반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[C:13]([O-:16])(=[O:15])[CH3:14].[K+].Cl>O>[C:13]([O:16][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10])(=[O:15])[CH3:14]참가 물질
5
실험 절차
A mixture of 2-(chloromethyl)benzenesulfonamide (2.00 g), potassium acetate (6.0 g) and water (75 ml) was heated to reflux for 1.5 hour. The pH was adjusted to ca. 5.0 by addition of hydrochloric acid and the chilled mixture was filtered to give 1.05 of of shiny white solid, m.p. 131°-133°. 'H NMR δ(CD3)2CO 8.00-7.83 (M), 7.60-7.25 (M), 6.55 (brd s), 5.47 (s), 2.97 (brd s), 2.10 (s), consistent with the assigned structure.
후처리
- temperaturewas heated
- temperatureto reflux for 1.5 hour
- filtrationthe chilled mixture was filtered
- customto give 1.05 of of shiny white solid, m.p. 131°-133°
출처 및 근거
- ORD 기록
- ord-439f86cf23e941daa85e51b148807256
- 출처 데이터셋
- uspto-grants-1982_06
- 특허 번호
- US04332611
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