Dimethylformamide → 2-(2-Methoxyphenyl)-2-methylpropanenitrile

반응식

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][C:6]#N.[CH3:12]I.[H-].[Na+].C[N:17]([CH3:20])C=O>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([C:20]#[N:17])([CH3:12])[CH3:6]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 81496(2-Methoxyphenyl)acetonitrile

생성물 1

HCID 101979202-(2-Methoxyphenyl)-2-methylpropanenitrile수율 85%

실험 절차

By a method analogous to that of Example 3(a), o-methoxybenzyl cyanide was methylated with methyl iodide and sodium hydride in dimethylformamide to give the desired compound in 85% yield.

출처 및 근거

ORD 기록: ord-c455276a076849faa4af107f42988fb5
출처 데이터셋: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04333759

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