Trichloroacetyl chloride → 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 1156717

반응식

HRID 1156717 반응식
[CH3:1][NH:2][C:3]1[S:7][N:6]=[C:5]([C:8]([Cl:11])([Cl:10])[Cl:9])[N:4]=1.[Cl:12][C:13]([Cl:18])([Cl:17])[C:14](Cl)=[O:15]>C1(C)C=CC=CC=1>[CH3:1][N:2]([C:3]1[S:7][N:6]=[C:5]([C:8]([Cl:11])([Cl:9])[Cl:10])[N:4]=1)[C:14](=[O:15])[C:13]([Cl:18])([Cl:17])[Cl:12]

참가 물질

4

반응물 2

HCID 6420Trichloroacetyl chlorideHCID 13150493N-Methyl-3-(trichloromethyl)-1,2,4-thiadiazol-5-amine

생성물 1

HCID 128516025-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole수율 92%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
-10 °C

실험 절차

A solution of 5.8 grams (0.02 mole) 5-methylamino-3-trichloromethyl-1,2,4-thiadiazole and 9.0 grams (0.05 mole) trichloroacetyl chloride in 200 milliliters toluene was refluxed at about 110° C. for 20 hours. Upon cooling to -10° C., 2.7 grams pure product precipitated; m.p. 223° C. An additional 6.0 grams product was isolated by removal of the low boiling materials in vacuo. Total yield was 92%.

후처리

  1. custom2.7 grams pure product precipitated

출처 및 근거

ORD 기록
ord-36de979bf96c461c9ee5e39d26fdcd9c
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337081

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