Hydrochloric Acid → N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid

HRID 1156855노트

반응식

HRID 1156855 반응식
[OH-].[Na+].C(O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([O:18]C)=[O:17])=[O:12].Cl>O>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([OH:18])=[O:17])=[O:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 12852881methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate

생성물 1

HCID 12852880N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid수율 76.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 20 ml of a 10% aqueous solution of sodium hydroxide and 10 ml of ethanol is added 0.95 g of methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate and the mixture is stirred at room temperature for 1 hour. The reaction mixture is poured into 100 ml of water and after cooling, hydrochloric acid is added to make the mixture weakly acidic. The precipitated crystals are collected by filtration and recrystallized from ethanol to obtain 0.7 g of N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid as colorless needles.

후처리

  1. temperatureafter cooling
  2. filtrationThe precipitated crystals are collected by filtration
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-ca415bc9bf2f4638b37f464c410206a9
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337270

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