Water → HCID 12851833, 화합물

HRID 1156871노트

반응식

HRID 1156871 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[C:13]([CH2:18]O)[CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:22])=O.O.[OH-].[Na+]>O1CCCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[C:13]([CH2:18][Cl:22])[CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 128518321-(4-Bromophenyl)-5-hydroxymethylisoquinoline

생성물 1

HCID 12851833HCID 12851833, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1-(4-Bromophenyl)-5-hydroxymethylisoquinoline (17 g) was dissolved in 300 ml of tetrahydrofuran, and 15 ml of phosphorus oxychloride was added. The mixture was stirred at room temperature for 1 hour. After the reaction, water was added, and the reaction mixture was neutralized with an aqueous solution of sodium hydroxide. The mixture was extracted with benzene, and dried. The solvent was distilled off. The residue was recrystallized from ether-hexane to afford 13.2 g of 1-(4-bromophenyl)-5-chloromethylisoquinoline as colorless prisms having a melting point of 115.5° to 118.5° C.

후처리

  1. additionwas added
  2. extractionThe mixture was extracted with benzene
  3. customdried
  4. distillationThe solvent was distilled off
  5. customThe residue was recrystallized from ether-hexane

출처 및 근거

ORD 기록
ord-c9da68286df54d1c92ed69eaca25b59c
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337256

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