Hydrochloric Acid → (R)-3-amino-1-carbomethoxymethyl-3,4-dihydrocarbostyril hydrochloride
반응식
C(OC([NH:8][C@@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:10]1=[O:24])=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[NH2:8][C@@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:10]1=[O:24]참가 물질
4
실험 절차
(R)-3-t-butyloxycarbonylamino-1-carbomethoxymethyl-3,4-dihydrocarbostyril (20 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (5 mL) at room temperature. After 1 h the solvent was evaporated under vacuum, and the residue was twice taken up in toluene (10 mL) and evaporated under vacuum to provide (R)-3-amino-1-carbomethoxymethyl-3,4-dihydrocarbostyril hydrochloride, a white solid (21 mg).