1-Butanol → 4-(4-Amino-phenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridin-3-ylamine

HRID 1159451노트

반응식

HRID 1159451 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:15]=[N:14][CH:13]=C(Cl)[C:9]=2[C:10]#[N:11])=[CH:4][CH:3]=1.[CH3:17][NH:18][NH2:19].[CH2:20](O)CCC>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:15]=[N:14][CH:13]=[C:17]3[N:18]([CH3:20])[N:19]=[C:10]([NH2:11])[C:9]=23)=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 2631-ButanolHCID 6061MethylhydrazineHCID 451233613-(4-Aminophenyl)-5-chloroisonicotinonitrile

생성물 1

HCID 686444744-(4-Amino-phenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridin-3-ylamine

실험 절차

The product from Example 1C (150 mg, 0.65 mmol) and methylhydrazine (0.35 mL) in n-butanol (2 mL) was heated in a sealed vial at 190° C. for 30 minutes with stirring in a Smith Synthesizer microwave oven (at 300W). The reaction mixture was allowed to cool to room temperature and partitioned between water and ethyl acetate. The organic extract was dried (Na2SO4), filtered, and the filtrate was concentrated to provide 0.08 g of the title compound. MS (ESI(+)) m/e 240 (M+H)+.

후처리

  1. custompartitioned between water and ethyl acetate
  2. extractionThe organic extract
  3. dry with materialwas dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-dd4d95861b45473a84a5f97180212f45
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812166B2

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