Phosphorus pentachloride → 4-(Methylsulfonyl)benzenemethanesulfonyl chloride

HRID 1159468노트

반응식

HRID 1159468 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12]([OH:15])(=O)=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[Na].P(Cl)(Cl)(Cl)(Cl)[Cl:18]>C(Cl)(Cl)Cl>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12]([Cl:18])(=[O:15])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 24819Phosphorus pentachlorideHCID 5360545SodiumHCID 17973788(4-Methanesulfonyl-phenyl)-methanesulfonic acid

생성물 1

HCID 219624184-(Methylsulfonyl)benzenemethanesulfonyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To the title A compound, (4-methanesulfonyl-phenyl)-methanesulfonic acid, sodium salt is added PCl5 (10 g) in 200 mL of chloroform and the mixture is stirred for 48 h. The solids are filtered off, the chloroform is removed by evaporation, and the residue is triturated with hexanes, and the solids are collected by filtration to afford (4-methanesulfonyl-phenyl)-methanesulfonyl chloride.

후처리

  1. filtrationThe solids are filtered off
  2. customthe chloroform is removed by evaporation
  3. customthe residue is triturated with hexanes
  4. filtrationthe solids are collected by filtration

출처 및 근거

ORD 기록
ord-825b500b5e5f4abaaab796bd4af3530e
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812167B2

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