Phosphorus tribromide → 1-(Bromomethyl)-2,4-dimethylbenzene

HRID 1159643

반응식

HRID 1159643 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH2:9]O.P(Br)(Br)[Br:12]>CCOCC>[Br:12][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 278092,4-Dimethylbenzyl alcohol

생성물 1

HCID 27346041-(Bromomethyl)-2,4-dimethylbenzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

5 g of (2,4-dimethylphenyl)methanol are dissolved in 100 ml of ether. The reaction mixture is cooled to 0° C. It is admixed dropwise with 5.2 ml of phosphorus tribromide. It is stirred at ambient temperature overnight. The reaction mixture is poured onto ice and extracted with AcOEt. The organic phase is washed with saturated NaCl solution. The organic phase is dried over MgSO4, filtered and evaporated to dryness. This gives 7.3 g of the expected compound.

후처리

  1. additionThe reaction mixture is poured onto ice
  2. extractionextracted with AcOEt
  3. washThe organic phase is washed with saturated NaCl solution
  4. dry with materialThe organic phase is dried over MgSO4
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d73d118dd0614b2d8413423dd397717a
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812165B2

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