Hydrochloric Acid → 1-(3-Chloro-2,4-dihydroxy-phenyl)ethanone

HRID 1161021

반응식

HRID 1161021 반응식
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:11])=[CH:8][C:9]=1[OH:10])=[O:3].[OH-].[Na+].[Cl:14][O-].[Na+].Cl>O>[Cl:14][C:8]1[C:9]([OH:10])=[C:4]([C:2](=[O:3])[CH3:1])[CH:5]=[CH:6][C:7]=1[OH:11]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 69902',4'-DihydroxyacetophenoneHCID 14798Sodium HydroxideHCID 23665760Sodium Hypochlorite

생성물 1

HCID 574382941-(3-Chloro-2,4-dihydroxy-phenyl)ethanone수율 65%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 2,4-dihydroxyacetophenone (6 g, 39.4 mmol), aqueous 1M sodium hydroxide (41.4 mL, 41.4 mmol) and water (200 mL) is stirred at room temperature. An aqueous 1.6M solution of sodium hypochlorite (32 mL) is added over a 1 hr period. The resulting dark brown solution is stirred 18 hr at room temperature. The reaction mixture is adjusted to a pH of 2-3 with concentrated aqueous hydrochloric acid. The resulting suspension is filtered and washed with water (4×100 mL). The filtered solid was dried under vacuum at 45° C. for 2.5 days to give the title compound (4.8 g, 65%) as a brown solid. LCMS 1 187 M+.

후처리

  1. filtrationThe resulting suspension is filtered
  2. washwashed with water (4×100 mL)
  3. customThe filtered solid was dried under vacuum at 45° C. for 2.5 days

출처 및 근거

ORD 기록
ord-c6985bac739c4f40be1b9f741ad7ff3b
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816523B2

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