Ethanol → 4-(5-Amino-1-benzofuran-7-yl)pyridine

HRID 1161984노트

반응식

HRID 1161984 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1)([O-])=O.C(O)C.O.NN>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1

참가 물질

6

반응물 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893958HCID 66893958, 화합물2회

생성물 1

HCID 668930874-(5-Amino-1-benzofuran-7-yl)pyridine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 312751,4-Dioxane용매

실험 절차

4-(5-Nitro-1-benzofuran-7-yl)pyridine (125 mg, 0.520 mmol; Intermediate 11) was dissolved in 1,4-dioxane (15 mL). After addition of ethanol (20 mL), Raney-nickel (slurry in ethanol; 2 mL) and hydrazine hydrate (4 mL) were added and the mixture was left stirring at room temperature overnight. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

후처리

  1. additionwere added
  2. waitthe mixture was left
  3. customThe product was used directly in the subsequent reaction
  4. filtrationafter filtration
  5. customthrough Celite and evaporation of solvent

출처 및 근거

ORD 기록
ord-f1e37edef826442c9d9c704dbfd9df1c
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820675B2

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