Ethanol → N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

HRID 1162001노트

반응식

HRID 1162001 반응식
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([N+:19]([O-])=O)[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)C.O.NN>C1COCC1.[Ni]>[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([NH2:19])[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

6

반응물 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893941HCID 66893941, 화합물2회

생성물 1

HCID 86058078N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

(2-Morpholin-4-ylethyl)(5-nitro-1-benzofuran-7-yl)amine (450 mg, 1.545 mmol; Intermediate 27) was dissolved in THF (5 mL). After addition of ethanol (100 mL), Raney-nickel (cat.) and hydrazine hydrate (2 mL), the mixture was left stirring at room temperature for 2 h. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

후처리

  1. waitthe mixture was left
  2. customThe product was used directly in the subsequent reaction
  3. filtrationafter filtration
  4. customthrough Celite and evaporation of solvent

출처 및 근거

ORD 기록
ord-0f165c00b7cd496896c1e4dd1ff174f4
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820675B2

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