Methyl iodide → methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate

HRID 1163096노트

반응식

HRID 1163096 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)=[CH:2]1.[H-].[Na+].[CH3:23]I>C1COCC1>[CH3:23][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)=[CH:2]1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 26367194methyl 4-((1H-indol-3-yl)methyl)benzoate

생성물 1

HCID 58970761methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of methyl 4-((1H-indol-3-yl)methyl)benzoate (0.250 g, 0.94 mmol) in THF is added dropwise to a suspension of NaH (0.048 g, 1.19 mmol) in THF. The mixture is stirred for 15 minutes, treated with methyl iodide (0.154 g, 1.08 mmol), stirred for 30 minutes and concentrated in vacuo. The resultant solid residue is partioned between CH2Cl2 and H2O. The organic phase is separated, dried over Na2SO4 and concentrated to dryness to yield methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate.

후처리

  1. stirringstirred for 30 minutes
  2. concentrationconcentrated in vacuo
  3. customThe organic phase is separated
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-0c72bbc334f348298ae8a70e538aa13d
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820825B2

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