Benzenesulfonyl chloride → N-(2-Amino-2-methylpropyl)benzenesulfonamide

HRID 1164993노트

반응식

HRID 1164993 반응식
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].[C:7]1([S:13](Cl)(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.N1C=CC=CC=1>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][S:13]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:15])=[O:14]

참가 물질

5

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 131282-Methylpropylenediamine

생성물 1

HCID 23046101N-(2-Amino-2-methylpropyl)benzenesulfonamide수율 79.1%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

To a mixture of 14.97 g (0.196 mol) of 1,2-diamino-2-methyl-propane in 300 ml of chloroform and 80 ml pyridine at 0° C. was added 10 g (0.057 mol) of benzenesulfonyl chloride at 0° C. The reaction mixture was stirred at 0° C. for 30 minutes and allowed to reach room temperature. The mixture was evaporated to dryness in vacuo and the residue was partitioned between water and chloroform. Evaporation of the chloroform gave 10.3 g (79%) of semisolid. The product was identified by NMR and IR spectroscopy and elemental analysis.

후처리

  1. customto reach room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customthe residue was partitioned between water and chloroform
  4. customEvaporation of the chloroform

출처 및 근거

ORD 기록
ord-8207e34f7d474dd286bff7a996e667f7
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906661

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