Hydrochloric Acid → trans-1-Benzoyl-4-phenyl-l-proline

HRID 1165965

반응식

HRID 1165965 반응식
[Cl-].[Cl-].[Cl-].[Al+3].[C:5]([N:13]1[CH2:20][C@@H:19](F)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl>C1C=CC=CC=1>[C:5]([N:13]1[CH2:20][C@H:19]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 14584914(cis)-1-Benzoyl-4-fluoro-L-proline

생성물 1

HCID 46864073trans-1-Benzoyl-4-phenyl-l-proline

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A suspension of aluminum trichloride (191 mg, 1.43 mmole) in benzene (5 ml) was stirred under argon and treated with Part B (cis)-N-benzoyl-4-fluoro-L-proline (100 mg, 0.42 mmole). The reaction was stirred at room temperature for 20 hours, cooled to 0° C. and hydrolyzed with 1N HCl. The layers were separated and the aqueous layer was extracted with ethyl acetate. The organic extracts were combined, washed with brine, dried and concentrated. The residue consisted of

후처리

  1. stirringThe reaction was stirred at room temperature for 20 hours
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5d1c8a6155244098807a146718398f92
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04912231

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