Dimethylformamide → (S)-3-Cyclohexylbutyroyl Chloride
반응식
[C:1]1([C@@H:7]([CH3:12])[CH2:8][C:9](O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>CO.C1(C)C=CC=CC=1.[Rh]>[CH:1]1([C@@H:7]([CH3:12])[CH2:8][C:9]([Cl:16])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
7
실험 절차
(S)-3-phenylbutyric acid was hydrogenated using Rh/C in MeOH at 60 psi and 60° C. for 3.2 hours. The reduced product was then converted to the title acid chloride by treating with 1 eq of oxalyl chloride, and a catalytic amount of DMF, in toluene for 90 minutes, followed by evaporation of the volatile materials.
후처리
- customat 60 psi and 60° C.
- customfor 3.2 hours
- customfollowed by evaporation of the volatile materials
출처 및 근거
- ORD 기록
- ord-e425d4f156254adc9d08a4f60024b1b6
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06613880B2
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