Water → N-(2-hydroxy-5-methoxyphenyl)acetamide

HRID 1167607노트

반응식

HRID 1167607 반응식
[NH2:1][C:2]1(O)[CH:7]=[CH:6]C(OC)=C[CH2:3]1.[C:11]([O:14][C:15](=O)[CH3:16])(=O)C.[C:18]([O-])(=[O:20])[CH3:19].[Na+].[OH2:23]>Cl>[OH:23][C:7]1[CH:6]=[CH:16][C:15]([O:14][CH3:11])=[CH:3][C:2]=1[NH:1][C:18](=[O:20])[CH3:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 22993362HCID 22993362, 화합물

생성물 1

HCID 817992N-(2-hydroxy-5-methoxyphenyl)acetamide

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The compound obtained in Step A (1 g; 7.19 mmol) is dissolved in 16 ml of water with the aid of concentrated hydrochloric acid (0.58 ml). Acetic anhydride (1.2 eq.; 8.62 mmol; 813 μl) is added to the red solution obtained. The mixture is homogenised and poured into 5 ml of a sodium acetate solution (1.7 eq.; 12.22 mmol; 1.075 g). After stirring the mixture for 15 minutes, the precipitate is filtered off using a Büchner funnel and then rinsed with water. The solid is subsequently dissolved in ethyl acetate and then dried over MgSO4. After filtration, the solvent is removed under reduced pressure to yield the title product in the form of a red solid.

후처리

  1. customobtained
  2. stirringAfter stirring the mixture for 15 minutes
  3. filtrationthe precipitate is filtered off
  4. washrinsed with water
  5. dissolutionThe solid is subsequently dissolved in ethyl acetate
  6. dry with materialdried over MgSO4
  7. filtrationAfter filtration
  8. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-80f757633f4140a28c8f8c39ee725a2d
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620809B2

반응 노트

불러오는 중…