Water → 1-Bromo-2-(propoxymethyl)benzene

HRID 1169474노트

반응식

HRID 1169474 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[H-].[Na+].Br[CH2:13][CH2:14][CH3:15].O>C1COCC1>[CH2:13]([O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[Br:1])[CH2:14][CH3:15]

참가 물질

6

반응물 4

HCID 962WaterHCID 78401-BromopropaneHCID 24758Sodium hydrideHCID 728502-Bromobenzyl alcohol

생성물 1

HCID 229900231-Bromo-2-(propoxymethyl)benzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Into a solution of 2-bromobenzyl alcohol (10.0 g) in THF (100 ml) was added at 0° C. sodium hydride (60%, 2.35 g), and the resulting mixture was stirred at room temperature for 2 hours. 1-Bromopropane (5.8 ml) was added to the reaction mixture, which was stirred at 60° C. for 20 hours. The reaction mixture was mixed with water and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride and was dried with magnesium sulfate. After concentration under reduced pressure, the residue was subjected to separation and purification using column chromatography (ethyl acetate:hexane 1:9) to obtain 2-bromobenzyl propyl ether (7.88 g) as a colorless oily substance.

후처리

  1. stirringwas stirred at 60° C. for 20 hours
  2. extractionwas extracted with ethyl acetate
  3. washThe organic layer was washed with an aqueous saturated solution of sodium chloride
  4. dry with materialwas dried with magnesium sulfate
  5. concentrationAfter concentration under reduced pressure
  6. customthe residue was subjected to separation and purification

출처 및 근거

ORD 기록
ord-9c017f2c0c924d51b06146f08378ef2e
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

반응 노트

불러오는 중…