Stannous Chloride → 2-Amino-5-fluorobenzonitrile

HRID 1169985노트

반응식

HRID 1169985 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12])([O-])=O.Cl[Sn]Cl>Cl>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12]

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 37564675-Fluoro-2-nitrobenzonitrile

생성물 1

HCID 27377042-Amino-5-fluorobenzonitrile

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The title compound was synthesized from commercially available 2-nitro-5-fluorobenzenecarbonitrile via reduction with SnCl2 in concentrated HCl as previously described in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: Hunziker, F. et al. Eur. J. Med. Chem., Chim. Ther. 1981, 16(5), 391. GC/MS m/z: 136.1 (M+, 100%), Rt 8.87 minutes.

출처 및 근거

ORD 기록
ord-01cbccf3425e409f9d5ffa2a1318af5c
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825132B2

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