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Sodium Hydroxide → 2-[(1S,2R)-1,2-diphenyl-2-propoxyethyl]-1,2-thiazolidine 1,1-dioxide

HRID 1170394
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HRID 1170394 반응식
[O:1]=[S:2]1(=[O:22])[CH2:6][CH2:5][CH2:4][N:3]1[C@@H:7]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C@@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[OH:9].[OH-].[Na+].[CH2:25](I)[CH2:26][CH3:27]>CS(C)=O.O>[C:16]1([C@H:7]([N:3]2[CH2:4][CH2:5][CH2:6][S:2]2(=[O:22])=[O:1])[C@@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:9][CH2:25][CH2:26][CH3:27])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 67524037HCID 67524037, 화합물

생성물 1

HCID 120033822-[(1S,2R)-1,2-diphenyl-2-propoxyethyl]-1,2-thiazolidine 1,1-dioxide

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

The product obtained from stage b) (70 mg, 0.221 mmol) was dissolved in 1 ml of DMSO, and 110 mg of powdered NaOH and then 169 mg (0.995 mmol) of n-propyl iodide were added. The reaction mixture was stirred at room temperature for 1.5 hours and then diluted with water. The crystalline precipitate obtained thereby was filtered off with suction. After drying, the material was stirred several times with n-heptane. 14.5 mg of (1S,2R)-2-(1,2-diphenyl-2-propoxyethyl)isothiazolidine 1,1-dioxide were obtained.

후처리

  1. customThe crystalline precipitate obtained
  2. filtrationthereby was filtered off with suction
  3. customAfter drying
  4. stirringthe material was stirred several times with n-heptane

출처 및 근거

ORD 기록
ord-79108b8bc8424ed5a5d8b3f0cfe985c0
출처 데이터셋
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07825264B2

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