Piperonal → HCID 67373916, 화합물

HRID 1170715

반응식

HRID 1170715 반응식
[CH2:1]([C:8]1[N:12]([CH:13]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:14]([NH:16][CH:17]2[CH2:22]C[CH2:20][CH2:19][CH2:18]2)=[O:15])[C:11]2[CH:29]=[C:30]([Cl:34])[C:31]([F:33])=[CH:32][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([CH:41]=[O:42])CCCCC1.C1C(C=O)=CC2[O:51][CH2:52][O:53]C=2C=1.ClC1C=C(CC(O)=O)C=CC=1.C1(C(OC)C(O)=O)CCCCC1.C1([N+]#[C-])CCCCC1.C1([N+]#[C-])CCCC1>>[O:51]1[C:26]2[CH:27]=[CH:28][C:23]([CH:13]([N:12]3[C:11]4[CH:29]=[C:30]([Cl:34])[C:31]([F:33])=[CH:32][C:10]=4[N:9]=[C:8]3[CH:1]([CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]3)[O:42][CH3:41])[C:14]([NH:16][CH:17]3[CH2:22][CH2:20][CH2:19][CH2:18]3)=[O:15])=[CH:24][C:25]=2[O:53][CH2:52]1

참가 물질

8

반응물 7

HCID 8438PiperonalHCID 158793-Chlorophenylacetic acidHCID 16275CyclohexanecarboxaldehydeHCID 79129Cyclohexyl isocyanideHCID 2734784Cyclopentyl IsocyanideHCID 215051022-Cyclohexyl-2-methoxyacetic acidHCID 673736232-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide

생성물 1

HCID 67373916HCID 67373916, 화합물

실험 절차

The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with piperonal ([CAS RN 120-57-0]), (3-chloro-phenyl)-acetic acid with DL-cyclohexyl-methoxy-acetic acid ([CAS RN 15540-18-8]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 542.3 [M+H]+.

출처 및 근거

ORD 기록
ord-3f6a9325fc534bb69c70eb0b1fd32576
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825258B2

연결된 노트

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