Benzyl Chloride → Ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate

HRID 1171

반응식

HRID 1171 반응식
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:21](Cl)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>ClCCl>[CH2:21]([N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH2:6][CH2:5]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 7503Benzyl ChlorideHCID 11266913Ethyl 5-(piperazin-1-yl)benzofuran-2-carboxylate

생성물 1

HCID 23508728Ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1 g of ethyl 5-(1-piperazinyl)-benzofuran-2-carboxylate in 50 ml of dichloromethane is treated with 1 g of benzyl chloride and stirred for 2 hours. After customary working up, ethyl 5-(4-benzyl-1-piperazinyl)benzofuran-2-carboxylate, m.p. 219°-222°, is obtained.

출처 및 근거

ORD 기록
ord-9767918db3564609a907b285260c24dc
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723614

연결된 노트

불러오는 중…