1H-imidazole-2-carbaldehyde → 1-(1H-Imidazol-2-ylmethyl)-5-phenoxy-1,2,3,4-tetrahydro-quinoline
반응식
[O:1]([C:8]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH:23]=O.C([BH3-])#N.[Na+]>CO.[Cl-].[Zn+2].[Cl-]>[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][N:13]1[C:14]2[C:9](=[C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:11][CH2:12]1참가 물질
6
실험 절차
Prepared analogously to Example 1, from 5-phenoxy-1,2,3,4-tetrahydro-quinoline, imidazole-2-carboxaldehyde, zinc chloride and sodium cyanoborohydride in methanol. MS (ISP): 306.3 ([M+H]+).
출처 및 근거
- ORD 기록
- ord-a086ec077fea473b88ffcff308ab65b2
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834044B2
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