1H-imidazole-2-carbaldehyde → 1-(1H-Imidazol-2-ylmethyl)-5-phenoxy-1,2,3,4-tetrahydro-quinoline

HRID 1172999

반응식

HRID 1172999 반응식
[O:1]([C:8]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH:23]=O.C([BH3-])#N.[Na+]>CO.[Cl-].[Zn+2].[Cl-]>[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][N:13]1[C:14]2[C:9](=[C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:11][CH2:12]1

참가 물질

6

반응물 3

HCID 249551H-imidazole-2-carbaldehydeHCID 4875475-Phenoxy-1,2,3,4-tetrahydroquinolineHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 247862311-(1H-Imidazol-2-ylmethyl)-5-phenoxy-1,2,3,4-tetrahydro-quinoline

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 887Methanol용매

실험 절차

Prepared analogously to Example 1, from 5-phenoxy-1,2,3,4-tetrahydro-quinoline, imidazole-2-carboxaldehyde, zinc chloride and sodium cyanoborohydride in methanol. MS (ISP): 306.3 ([M+H]+).

출처 및 근거

ORD 기록
ord-a086ec077fea473b88ffcff308ab65b2
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834044B2

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