Hydrochloric Acid → 4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic Acid

HRID 1173881노트

반응식

HRID 1173881 반응식
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:15][N:16]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:17][C:18]2[NH:19][CH:20]=[CH:21][N:22]=2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].Cl>CO>[NH:19]1[CH:20]=[CH:21][N:22]=[C:18]1[CH2:17][N:16]([CH2:15][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=1)[CH2:23][C:24]1[NH:28][CH:27]=[CH:26][N:25]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669413384-{[bis(1H-imidazol-2-ylmethyl)amino]methyl)naphthalene-1-carboxylic acid methyl ester

생성물 1

HCID 210844614-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic Acid수율 104.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound (675 mg) obtained in Example 36-3 was added with methanol (7.0 ml) and a 1 mol/l sodium hydroxide (7.0 ml), followed by stirring for 1 hour. After completion of the reaction, 1 mol/l hydrochloric acid (8.0 ml) was added to adjust the solution to pH 4. Then, the solvent was distilled off and the residue was washed with methanol, followed by drying. Consequently, the subject compound (677 mg) was obtained as a white solid.

후처리

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. washthe residue was washed with methanol
  4. customby drying

출처 및 근거

ORD 기록
ord-52fc4b43bc914f079566b45c9e703e50
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833991B2

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