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Sodium Hydroxide → (4-Aminomethylbenzyl)-(4-dipropylaminomethylphenyl)-amine

HRID 1173886
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HRID 1173886 반응식
[CH2:1]([N:4]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][C:17]2[CH:34]=[CH:33][C:20]([CH2:21][N:22]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].O.NN.[OH-].[Na+]>CO>[NH2:22][CH2:21][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][NH:15][C:12]2[CH:13]=[CH:14][C:9]([CH2:8][N:4]([CH2:5][CH2:6][CH3:7])[CH2:1][CH2:2][CH3:3])=[CH:10][CH:11]=2)=[CH:34][CH:33]=1
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참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 210843762-{4-[(4-Dipropylaminomethylphenylamino)methyl]benzyl}isoindole-1,3-dione

생성물 1

HCID 23079293(4-Aminomethylbenzyl)-(4-dipropylaminomethylphenyl)-amine수율 99.8%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

The compound (521.6 mg) obtained in Example 39-1 was dissolved in methanol (15 ml) and added with hydrazine monohydrate (0.11 ml), followed by stirring at 60° C. for 1.5 hours. The reaction solution was added with a 1 mol/l sodium hydroxide aqueous solution and then subjected to extraction with chloroform. Subsequently, the organic layer was washed with saturated saline solution and then dried with anhydrous sodium sulfate. After the solvent had been distilled off, the subject compound (372 mg) was obtained as a yellow solid.

후처리

  1. extractionsubjected to extraction with chloroform
  2. washSubsequently, the organic layer was washed with saturated saline solution
  3. dry with materialdried with anhydrous sodium sulfate
  4. distillationAfter the solvent had been distilled off

출처 및 근거

ORD 기록
ord-936a9b2789f2401a82e4e1577315b761
출처 데이터셋
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07833991B2

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