Hydrochloric Acid → (2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoic Acid

HRID 1174223노트

반응식

HRID 1174223 반응식
[CH2:1]([N:8]([CH3:21])[C:9]([NH:11][C@@H:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]([O:15]C)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+].Cl>O1CCOCC1>[CH2:1]([N:8]([CH3:21])[C:9]([NH:11][C@@H:12]([C:17]([CH3:19])([CH3:18])[CH3:20])[C:13]([OH:15])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67408150methyl(2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoate

생성물 1

HCID 61186392(2S)-2-({[benzyl(methyl)amino]carbonyl}amino)-3,3-dimethylbutanoic Acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
25 °C

실험 절차

A solution containing the product from Example 63B (0.046 g, 0.057 mmol) in dioxane (1.6 mL) was treated with an aqueous solution of lithium hydroxide (0.63 mL, 0.5 N), and the mixture was stirred at 25° C. for 16 hours. An aqueous HCl solution (0.60 mL, 1N) was added, the reaction mixture was partitioned between ethyl acetate and water, and the organic phase was washed with brine and dried over MgSO4, filtered and concentrated to give the crude product, which was used without further purification.

후처리

  1. customthe reaction mixture was partitioned between ethyl acetate and water
  2. washthe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b282b8235d7e4ba997e1c9477abb7793
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834043B2

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