4-Nitroanthranilic acid → 4-Nitro-isatoic anhydride

HRID 1175788노트

반응식

HRID 1175788 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([NH2:13])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-:3])=[O:2].Cl[C:15](Cl)([O:17]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCCC1>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]2[C:8](=[O:10])[O:9][C:15](=[O:17])[NH:13][C:6]=2[CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 120764-Nitroanthranilic acidHCID 94429Triphosgene

생성물 1

HCID 2820894-Nitro-isatoic anhydride수율 20,285.801%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
45 °C

실험 절차

A mixture of 4-nitroanthranilic acid (9.11 g), triphosgene (4.92 g) and tetrahydrofuran (240 ml) was stirred for 10 hours at 45° C. The precipitated solids were collected by filtration, washed with tetrahydrofuran, and then dried to obtain the target product (700 g).

후처리

  1. filtrationThe precipitated solids were collected by filtration
  2. washwashed with tetrahydrofuran
  3. customdried

출처 및 근거

ORD 기록
ord-02042def898647ecb57e7d9c13f875cd
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842701B2

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