Hydrochloric Acid → Duloxetine Hydrochloride

HRID 1176066

반응식

HRID 1176066 반응식
[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[ClH:22]>CCC(C)=O>[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[C:17]2[C:16](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:15]=[CH:14][CH:13]=1)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[ClH:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 60835Duloxetine

생성물 1

HCID 60834Duloxetine Hydrochloride수율 94.64%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

To a solution of 1 g of duloxetine in 10 ml MEK was slowly added 0.32 ml of a 37 percent hydrochloric acid solution. The mixture was stirred until a solid formed. The resulting solid was filtered, and dried in a vacuum oven to give 0.50 g of (S)-(+)-duloxetine hydrochloride. (94.64% yield).

후처리

  1. customformed
  2. filtrationThe resulting solid was filtered
  3. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-573d9e7849e74a3b9b1d1608f68b2736
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842717B2

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